Two international teams, one headed by Akhilesh Pandey and the other by Bernhard Küster, have independently analyzed human tissue samples using mass spectrometry and produced the first drafts of the human proteome. They discovered new complexities of the human genome and identified new proteins from regions of the genome previously thought to be non-coding. The curated catalogs of the proteins expressed in most non-diseased human tissues and organs can be used as a baseline to better understand changes that occur in disease states.
Read more in The Scientist.
M. Wilhelm et al., “Mass-spectrometry-based draft of the human proteome,” Nature, doi:10.1038/nature13319, 2014.